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In 2002, Duke University attempted to avoid liability for patent infringement by invoking the common law experimental research exception to patent infringement. In a landmark decision, the U.S. Court of Appeals for the Federal Circuit rejected Duke University's argument that its infringing research activities should be exempt from liability under this exception. Madey v. Duke Univ., 307 F.3d 1351 (Fed. Cir. 2002).
This decision led a number of commentators to proclaim that the experimental use doctrine has been eliminated, that patent holders will now aggressively pursue licensing with researchers and embolden their enforcement efforts, and that there will be a great chill on research efforts. University administrators complained that it would be impossible for them to monitor the activities of their research personnel for possible infringement.
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